Activation of Nrf2/HO-1 Pathway by Glycogen Synthase Kinase-3β Inhibition Attenuates Renal Ischemia/Reperfusion Injury in Diabetic Rats

Activation of Nrf2/HO-1 Pathway by Glycogen Synthase Kinase-3β Inhibition Attenuates Renal Ischemia/Reperfusion Injury in Diabetic Rats

Background/Aims: Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate the protective effect of GSK-3β inhibition (TDZD-8) on I/R-induced renal injury through the Nrf2/HO-1 pathway in a streptozocin (STZ)-induced diabetic rat m...

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Bibliographic Details
Main Authors: Xiaohua Shen, Bo Hu, Guangtao Xu, Fengjuan Chen, Ruifen Ma, Nenghua Zhang, Jie Liu, Xiaoqin Ma, Jia Zhu, Yuhong Wu, Ruilin Shen
Format: Article
Language:English
Published: Karger Publishers 2017-06-01
Series:Kidney & Blood Pressure Research
Subjects:
TDZD-8
Nrf2/HO-1
Bcl-2
NF-κB
Ischemia/reperfusion
Diabetes mellitus
Online Access:http://www.karger.com/Article/FullText/477947

Internet

http://www.karger.com/Article/FullText/477947

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