Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors.

The role of brain corticotropin-releasing factor type 2 (CRF2) receptors in behavioral stress responses remains controversial. Conflicting findings suggest pro-stress, anti-stress or no effects of impeding CRF2 signaling. Previous studies have used antisauvagine-30 as a selective CRF2 antagonist. Th...

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Bibliographic Details
Main Authors: Eric P Zorrilla, Amanda J Roberts, Jean E Rivier, George F Koob
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3756045?pdf=render