A genetic algorithm for the ligand-protein docking problem

A genetic algorithm for the ligand-protein docking problem

We analyzed the performance of a real coded "steady-state" genetic algorithm (SSGA) using a grid-based methodology in docking five HIV-1 protease-ligand complexes having known three-dimensional structures. All ligands tested are highly flexible, having more than 10 conformational degrees o...

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Bibliographic Details
Main Authors: Camila S. de Magalhães, Hélio J.C. Barbosa, Laurent E. Dardenne
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2004-01-01
Series:Genetics and Molecular Biology
Subjects:
ligand-protein docking
flexible docking
genetic algorithms
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400022

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400022

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