Competitive blocking of salivary gland [18F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

Competitive blocking of salivary gland [18F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study

Abstract Background PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radionuclides. With [18F]DCFPyL as a surrogate for PSMA-TRT, we report a nove...

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Bibliographic Details
Main Authors: Jyoti Roy, Blake M. Warner, Falguni Basuli, Xiang Zhang, Changyu Zheng, Corrine Goldsmith, Tim Phelps, Karen Wong, Anita T. Ton, Rick Pieschl, Margaret E. White, Rolf Swenson, John A. Chiorini, Peter L. Choyke, Frank I. Lin
Format: Article
Language:English
Published: SpringerOpen 2021-07-01
Series:EJNMMI Research
Subjects:
PSMA
Salivary glands
Radionuclide therapy
Cannulation
Prostate cancer
Xerostomia
Online Access:https://doi.org/10.1186/s13550-021-00803-9

Internet

https://doi.org/10.1186/s13550-021-00803-9

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