Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor

The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, lead...

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Bibliographic Details
Main Authors: Wei Deng, Yan Xu, Wenchun Chen, David S. Paul, Anum K. Syed, Matthew A. Dragovich, Xin Liang, Philip Zakas, Michael C. Berndt, Jorge Di Paola, Jerry Ware, Francois Lanza, Christopher B. Doering, Wolfgang Bergmeier, X. Frank Zhang, Renhao Li
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12863

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https://doi.org/10.1038/ncomms12863

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