Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis via the Liver HTR2A/PPARγ2 Pathway

Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis via the Liver HTR2A/PPARγ2 Pathway

The precipitous increase in occurrence of non-alcoholic steatohepatitis (NASH) is a serious threat to public health worldwide. The pathogenesis of NASH has not yet been thoroughly studied. We aimed to elucidate the interplay between serotonin (5-hydroxytryptamine, 5-HT) and NASH. The serum 5-HT leve...

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Bibliographic Details
Main Authors: Lulu Wang, Xiangcheng Fan, Jichun Han, Minxuan Cai, Xiaozhong Wang, Yan Wang, Jing Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
gut-derived serotonin
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
HTR2A
PPRAγ2
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00553/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00553/full

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