Animal Models of Interferon Signature Positive Lupus

Animal Models of Interferon Signature Positive Lupus

Human lupus is strongly associated with a gene expression signature characterized by over-expression of type I interferon-regulated genes. A strong interferon signature is not seen in the standard mouse models of lupus, despite considerable evidence for the involvement of toll-like receptor (TLR)-d...

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Bibliographic Details
Main Authors: Haoyang eZhuang, Christopher eSzeto, Shuhong eHan, Lijun eYang, Westley H. Reeves
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Immunology
Subjects:
Apoptosis
Lupus Erythematosus, Systemic
Toll-Like Receptors
Animal Models
B cell activation
interferon alpha
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00291/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00291/full

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