Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

Protein Kinase A (PKA) mediates synaptic plasticity and is widely implicated in learning and memory. The hippocampal dentate gyrus (DG) is thought to be responsible for processing and encoding distinct contextual associations in response to highly similar inputs. The mossy fiber (MF) axons of the de...

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Bibliographic Details
Main Authors: Brian W Jones, Jennifer Deem, Thomas J Younts, Michael Weisenhaus, Christina A Sanford, Margaret C Slack, Jenesa Chin, Daniela Nachmanson, Alex McKennon, Pablo E Castillo, G Stanley McKnight
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
PKA anchoring
synaptic plasticity
spatial discrimination
Online Access:https://elifesciences.org/articles/20695

Internet

https://elifesciences.org/articles/20695

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