CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction

CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction

Interaction between chemokine stromal cell-derived factor 1 and the CXC chemokine receptor 4 (CXCR4) governs the sequestration and mobilization of bone marrow stem cells. We investigated the therapeutic potential of TG-0054, a novel CXCR4 antagonist, in attenuating cardiac dysfunction after myocardi...

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Bibliographic Details
Main Authors: Wan-Tseng Hsu, Hsiang-Yiang Jui, Ying-Huey Huang, Mao-Yuan M. Su, Yen-Wen Wu, Wen-Yih I. Tseng, Ming-Chu Hsu, Bor-Luen Chiang, Kenneth K. Wu, Chii-Ming Lee M.D., Ph.D.
Format: Article
Language:English
Published: SAGE Publishing 2015-07-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368914X681739

Internet

https://doi.org/10.3727/096368914X681739

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