Targeting Beta-Amyloid at the CSF: A New Therapeutic Strategy in Alzheimer’s Disease

Targeting Beta-Amyloid at the CSF: A New Therapeutic Strategy in Alzheimer’s Disease

Although immunotherapies against the amyloid-β (Aβ) peptide tried so date failed to prove sufficient clinical benefit, Aβ still remains the main target in Alzheimer’s disease (AD). This article aims to show the rationale of a new therapeutic strategy: clearing Aβ from the CSF continuously (the “CSF-...

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Bibliographic Details
Main Authors: Manuel Menendez-Gonzalez, Huber S. Padilla-Zambrano, Gabriel Alvarez, Estibaliz Capetillo-Zarate, Cristina Tomas-Zapico, Agustin Costa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer disease
amyloid beta-peptides
cerebrospinal fluid
immunotherapy
“CSF sink hypothesis”
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00100/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2018.00100/full

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