Functional Dissection of the Dominant Role of CD55 in Protecting Vesicular Stomatitis Virus against Complement-Mediated Neutralization

Functional Dissection of the Dominant Role of CD55 in Protecting Vesicular Stomatitis Virus against Complement-Mediated Neutralization

The human complement system is an important part of the innate immune system. Its effector pathways largely mediate virus neutralization. Vesicular stomatitis virus (VSV) activates the classical pathway of the complement, leading to virus neutralization by lysis. Two host-derived membrane-associated...

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Bibliographic Details
Main Authors: Nisha Asok Kumar, Sreenath Muraleedharan Suma, Umerali Kunnakkadan, Joydeep Nag, Reshma Koolaparambil Mukesh, Douglas S. Lyles, John Bernet Johnson
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Viruses
Subjects:
vesicular stomatitis virus
complement
virus neutralization
viral resistance
membrane cofactor protein (CD46)
decay accelerating factor (CD55)
Online Access:https://www.mdpi.com/1999-4915/13/3/373

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https://www.mdpi.com/1999-4915/13/3/373

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