GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo

GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo

Abstract Background Insulin secretion from the pancreatic β-cell is finely modulated by different signals to allow an adequate control of glucose homeostasis. Incretin hormones such as glucagon-like peptide-1 (GLP-1) act as key physiological potentiators of insulin release through binding to the G p...

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Bibliographic Details
Main Authors: Alba C. Arcones, Rocío Vila-Bedmar, Mercedes Mirasierra, Marta Cruces-Sande, Mario Vallejo, Ben Jones, Alejandra Tomas, Federico Mayor, Cristina Murga
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Biology
Subjects:
Insulin signaling
Incretin
G protein-coupled receptor kinase 2 (GRK2)
Glucagon-like peptide 1 (GLP-1)
β-arrestin
Granule dynamics
Online Access:https://doi.org/10.1186/s12915-021-00966-w

Internet

https://doi.org/10.1186/s12915-021-00966-w

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