PI3K (Phosphatidylinositol 3-Kinase) Activation and Endothelial Cell Proliferation in Patients with Hemorrhagic Hereditary Telangiectasia Type 1

PI3K (Phosphatidylinositol 3-Kinase) Activation and Endothelial Cell Proliferation in Patients with Hemorrhagic Hereditary Telangiectasia Type 1

Hemorrhagic hereditary telangiectasia (HHT) type 2 patients have increased activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway in telangiectasia. The main objective is to evaluate the activation of the PI3K pathway in cutaneous telangiectasia of HHT1 patients. A cutaneous biopsy...

Full description

Bibliographic Details
Main Authors: Adriana Iriarte, Agnes Figueras, Pau Cerdà, José María Mora, Anna Jucglà, Rosa Penín, Francesc Viñals, Antoni Riera-Mestre
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
hemorrhagic hereditary telangiectasia
rare diseases
telangiectasia
transforming growth factor-beta (TGF-β)
Smad pathway
phosphatidylinositol 3-kinase
mTOR inhibitors
Online Access:https://www.mdpi.com/2073-4409/8/9/971

Internet

https://www.mdpi.com/2073-4409/8/9/971

Similar Items