Mechanisms Underlying the Strong Inhibition of Muscle-Type Nicotinic Receptors by Tetracaine

Mechanisms Underlying the Strong Inhibition of Muscle-Type Nicotinic Receptors by Tetracaine

Nicotinic acetylcholine (ACh) receptors (nAChRs) are included among the targets of a variety of local anesthetics, although the molecular mechanisms of blockade are still poorly understood. Some local anesthetics, such as lidocaine, act on nAChRs by different means through their ability to present a...

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Bibliographic Details
Main Authors: Raúl Cobo, Magdalena Nikolaeva, Armando Alberola-Die, Gregorio Fernández-Ballester, José M. González-Ros, Isabel Ivorra, Andrés Morales
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
tetracaine
nicotinic acetylcholine receptors
Xenopus oocytes
microtransplanted receptors
desensitization
mechanisms of blockade
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00193/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00193/full

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