Doxycycline and hydroxypropyl-β-cyclodextrin complex in poloxamer thermal sensitive hydrogel for ophthalmic delivery

The present study aimed to prepare a chemically and physically stable formulation of doxycycline (Doxy) in an in situ thermally sensitive hydrogel for ophthalmic delivery. An inclusion complex of Doxy and hydroxypropyl-β-cyclodextrin (HP-β-CD) was first developed to increase the stability of Doxy in...

Full description

Bibliographic Details
Main Authors: Zi-xin He, Zhou-hua Wang, Hao-hao Zhang, Xin Pan, Wen-ru Su, Dan Liang, Chuan-bin Wu
Format: Article
Language:English
Published: Elsevier 2011-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383511000840