Cannabidiol (CBD) Inhibited Rhodamine-123 Efflux in Cultured Vascular Endothelial Cells and Astrocytes Under Hypoxic Conditions

Cannabidiol (CBD) Inhibited Rhodamine-123 Efflux in Cultured Vascular Endothelial Cells and Astrocytes Under Hypoxic Conditions

Despite the constant development of new antiepileptic drugs (AEDs), more than 30% of patients develop refractory epilepsy (RE) characterized by a multidrug-resistant (MDR) phenotype. The “transporters hypothesis” indicates that the mechanism of this MDR phenotype is the overexpression of ABC transpo...

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Bibliographic Details
Main Authors: Jerónimo Auzmendi, Pablo Palestro, Agustín Blachman, Luciana Gavernet, Amalia Merelli, Alan Talevi, Graciela Cristina Calabrese, Alberto Javier Ramos, Alberto Lazarowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
cannabidiol
P-glycoprotein
hypoxia
endothelial cells
astrocytes
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2020.00032/full

Internet

https://www.frontiersin.org/article/10.3389/fnbeh.2020.00032/full

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