Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

Hybrid nanoparticles from lipidic and polymeric components were assembled to serve as vehicles for the transfection of messenger RNA (mRNA) using different portions of the cationic lipid DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) and the cationic biopolymer protamine as model systems. Two diff...

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Bibliographic Details
Main Authors: Christian D. Siewert, Heinrich Haas, Vera Cornet, Sara S. Nogueira, Thomas Nawroth, Lukas Uebbing, Antje Ziller, Jozef Al-Gousous, Aurel Radulescu, Martin A. Schroer, Clement E. Blanchet, Dmitri I. Svergun, Markus P. Radsak, Ugur Sahin, Peter Langguth
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
vaccination
Covid-19
cancer immunotherapy
RNA
cationic polymer
cationic lipid
Online Access:https://www.mdpi.com/2073-4409/9/9/2034

Internet

https://www.mdpi.com/2073-4409/9/9/2034

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