Opposing Effects on Vascular Smooth Muscle Cell Proliferation and Macrophage-induced Inflammation Reveal a Protective Role for the Proresolving Lipid Mediator Receptor ChemR23 in Intimal Hyperplasia

Opposing Effects on Vascular Smooth Muscle Cell Proliferation and Macrophage-induced Inflammation Reveal a Protective Role for the Proresolving Lipid Mediator Receptor ChemR23 in Intimal Hyperplasia

Intimal hyperplasia remains a significant clinical problem in for example coronary artery bypass graft failure. Since omega-3 fatty acids reduce intimal hyperplasia, we hypothesized that the G protein-coupled receptor ChemR23 for the omega-3-derived pro-resolving lipid mediator resolvin E1 drives th...

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Bibliographic Details
Main Authors: Gonzalo Artiach, Miguel Carracedo, Joan Clària, Andres Laguna-Fernandez, Magnus Bäck
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
intimal hyperplasia
macrophage
omega-3
resolution of inflammation
smooth muscle cells
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01327/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01327/full

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