Structural dynamics of the yeast Shwachman-Diamond syndrome protein (Sdo1) on the ribosome and its implication in the 60S subunit maturation

Structural dynamics of the yeast Shwachman-Diamond syndrome protein (Sdo1) on the ribosome and its implication in the 60S subunit maturation

Abstract The human Shwachman-Diamond syndrome (SDS) is an autosomal recessive disease caused by mutations in a highly conserved ribosome assembly factor SBDS. The functional role of SBDS is to cooperate with another assembly factor, elongation factor 1-like (Efl1), to promote the release of eukaryot...

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Bibliographic Details
Main Authors: Chengying Ma, Kaige Yan, Dan Tan, Ningning Li, Yixiao Zhang, Yi Yuan, Zhifei Li, Meng-Qiu Dong, Jianlin Lei, Ning Gao
Format: Article
Language:English
Published: SpringerOpen 2016-02-01
Series:Protein & Cell
Subjects:
ribosome biogenesis
SBDS
SDS
Sdo1
cryo-electron microscopy (cryo-EM)
Online Access:http://link.springer.com/article/10.1007/s13238-015-0242-5

Internet

http://link.springer.com/article/10.1007/s13238-015-0242-5

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