Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import

While Sec61 enables ER import of all polypeptides with N-terminal signal peptides, only selected clients are accepted for TRAP-assisted ER import. Here, the authors use a proteomics approach to characterize TRAP-dependent clients, identifying signal peptide features that govern recognition by TRAP.

Bibliographic Details
Main Authors: Duy Nguyen, Regine Stutz, Stefan Schorr, Sven Lang, Stefan Pfeffer, Hudson H. Freeze, Friedrich Förster, Volkhard Helms, Johanna Dudek, Richard Zimmermann
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06188-z

Internet

https://doi.org/10.1038/s41467-018-06188-z

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