Single Tyrosine Mutation in AAV8 Vector Capsid Enhances Gene Lung Delivery and Does Not Alter Lung Morphofunction in Mice

Single Tyrosine Mutation in AAV8 Vector Capsid Enhances Gene Lung Delivery and Does Not Alter Lung Morphofunction in Mice

Background/Aims: Vectors derived from adeno-associated viruses (AAVs) are important gene delivery tools for treating pulmonary diseases. Phosphorylation of surface-exposed tyrosine residues from AAV2 capsid targets the viral particles for ubiquitination and proteasome-mediated degradation, and mutat...

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Bibliographic Details
Main Authors: Sabrina V. Martini, Adriana L. da Silva, Debora Ferreira, Karina Gomes, Felipe M. Ornellas, Miquéias Lopes-Pacheco, Emilia Zin, Hilda Petrs-Silva, Patricia R. M. Rocco, Marcelo M. Morales
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Tyrosine mutant
Lung function
Adeno-associated virus
Gene therapy
Online Access:http://www.karger.com/Article/FullText/363033

Internet

http://www.karger.com/Article/FullText/363033

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