Chromosome mis-segregation and cytokinesis failure in trisomic human cells

Chromosome mis-segregation and cytokinesis failure in trisomic human cells

Cancer cells display aneuploid karyotypes and typically mis-segregate chromosomes at high rates, a phenotype referred to as chromosomal instability (CIN). To test the effects of aneuploidy on chromosome segregation and other mitotic phenotypes we used the colorectal cancer cell line DLD1 (2n = 46) a...

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Bibliographic Details
Main Authors: Joshua M Nicholson, Joana C Macedo, Aaron J Mattingly, Darawalee Wangsa, Jordi Camps, Vera Lima, Ana M Gomes, Sofia Dória, Thomas Ried, Elsa Logarinho, Daniela Cimini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-05-01
Series:eLife
Subjects:
chromosome
aneuploidy
cancer
mis-segregation
CIN
cytokinesis
Online Access:https://elifesciences.org/articles/05068

Internet

https://elifesciences.org/articles/05068

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