MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage

MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage

Microvascular endothelial cells maintain a tight barrier to prevent passage of plasma and circulating immune cells into the extravascular tissue compartment, yet endothelial cells respond rapidly to vasoactive substances, including thrombin, allowing transient paracellular permeability. This respons...

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Bibliographic Details
Main Authors: Linda R. Klei, Dong Hu, Robert Panek, Danielle N. Alfano, Rachel E. Bridwell, Kelly M. Bailey, Katherine I. Oravecz-Wilson, Vincent J. Concel, Emily M. Hess, Matthew Van Beek, Phillip C. Delekta, Shufang Gu, Simon C. Watkins, Adrian T. Ting, Peter J. Gough, Kevin P. Foley, John Bertin, Linda M. McAllister-Lucas, Peter C. Lucas
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
NF-κB
thrombin
Protease activated receptor-1 (PAR1)
CARMA3
CARD10
Bcl10
G protein-coupled receptor (GPCR)
endothelial permeability
MALT1 protease
CYLD
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311767

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http://www.sciencedirect.com/science/article/pii/S2211124716311767

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