The E3 ligase UBR2 regulates cell death under caspase deficiency via Erk/MAPK pathway

Abstract Escape from cell death is a key event in cancer establishment/progression. While apoptosis is often considered as the main cell death pathway, upon caspase inhibition, cell death is rather delayed than blocked leading to caspase-independent cell death (CICD). Although described for years, C...

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Bibliographic Details
Main Authors: Elodie Villa, Rachel Paul, Ophélie Meynet, Sophie Volturo, Guillaume Pinna, Jean-Ehrland Ricci
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03258-3