Safety, tolerability, and immunogenicity of influenza vaccination with a high-density microarray patch: Results from a randomized, controlled phase I clinical trial.

BACKGROUND:The Vaxxas high-density microarray patch (HD-MAP) consists of a high density of microprojections coated with vaccine for delivery into the skin. Microarray patches (MAPs) offer the possibility of improved vaccine thermostability as well as the potential to be safer, more acceptable, easie...

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Main Authors: Angus H Forster, Katey Witham, Alexandra C I Depelsenaire, Margaret Veitch, James W Wells, Adam Wheatley, Melinda Pryor, Jason D Lickliter, Barbara Francis, Steve Rockman, Jesse Bodle, Peter Treasure, Julian Hickling, Germain J P Fernando
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-03-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1003024