Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

Liver mitochondrial metabolism plays an important role for glucose and lipid homeostasis and its alterations contribute to metabolic disorders, including fatty liver and diabetes. Here Perry et al. develop a method for the measurement of hepatic fluxes by using lactate and glucose tracers in combina...

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Main Authors:	Rachel J. Perry, Liang Peng, Gary W. Cline, Gina M. Butrico, Yongliang Wang, Xian-Man Zhang, Douglas L. Rothman, Kitt Falk Petersen, Gerald I. Shulman
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01143-w

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spelling	doaj-ccfedb92246c4972a9596277dbe5a31b2021-05-11T07:14:10ZengNature Publishing GroupNature Communications2041-17232017-10-01811910.1038/s41467-017-01143-wNon-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)Rachel J. Perry0Liang Peng1Gary W. Cline2Gina M. Butrico3Yongliang Wang4Xian-Man Zhang5Douglas L. Rothman6Kitt Falk Petersen7Gerald I. Shulman8Departments of Internal Medicine, Yale University School of MedicineDepartments of Internal Medicine, Yale University School of MedicineDepartments of Internal Medicine, Yale University School of MedicineDepartments of Internal Medicine, Yale University School of MedicineDepartments of Internal Medicine, Yale University School of MedicineDepartments of Internal Medicine, Yale University School of MedicineDepartments of Radiology and Biomedical Imaging, Yale University School of MedicineDepartments of Internal Medicine, Yale University School of MedicineDepartments of Internal Medicine, Yale University School of MedicineLiver mitochondrial metabolism plays an important role for glucose and lipid homeostasis and its alterations contribute to metabolic disorders, including fatty liver and diabetes. Here Perry et al. develop a method for the measurement of hepatic fluxes by using lactate and glucose tracers in combination with NMR spectroscopy.https://doi.org/10.1038/s41467-017-01143-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rachel J. Perry Liang Peng Gary W. Cline Gina M. Butrico Yongliang Wang Xian-Man Zhang Douglas L. Rothman Kitt Falk Petersen Gerald I. Shulman
spellingShingle	Rachel J. Perry Liang Peng Gary W. Cline Gina M. Butrico Yongliang Wang Xian-Man Zhang Douglas L. Rothman Kitt Falk Petersen Gerald I. Shulman Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA) Nature Communications
author_facet	Rachel J. Perry Liang Peng Gary W. Cline Gina M. Butrico Yongliang Wang Xian-Man Zhang Douglas L. Rothman Kitt Falk Petersen Gerald I. Shulman
author_sort	Rachel J. Perry
title	Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
title_short	Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
title_full	Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
title_fullStr	Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
title_full_unstemmed	Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
title_sort	non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer nmr tracer analysis (pinta)
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-10-01
description	Liver mitochondrial metabolism plays an important role for glucose and lipid homeostasis and its alterations contribute to metabolic disorders, including fatty liver and diabetes. Here Perry et al. develop a method for the measurement of hepatic fluxes by using lactate and glucose tracers in combination with NMR spectroscopy.
url	https://doi.org/10.1038/s41467-017-01143-w
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Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

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