Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.

Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma.

The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is frequently activated in human cancer and plays a crucial role in glioblastoma biology. We were interested in gaining further insight into the potential of targeting PI3K isoforms as a novel anti-tumor approach i...

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Bibliographic Details
Main Authors: Katrin Höland, Danielle Boller, Christian Hagel, Silvia Dolski, András Treszl, Olivier E Pardo, Paulina Cwiek, Fabiana Salm, Zaira Leni, Peter R Shepherd, Beata Styp-Rekowska, Valentin Djonov, André O von Bueren, Karl Frei, Alexandre Arcaro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3981776?pdf=render

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http://europepmc.org/articles/PMC3981776?pdf=render

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