Mucosal Nanoemulsion Allergy Vaccine Suppresses Alarmin Expression and Induces Bystander Suppression of Reactivity to Multiple Food Allergens

Mucosal Nanoemulsion Allergy Vaccine Suppresses Alarmin Expression and Induces Bystander Suppression of Reactivity to Multiple Food Allergens

We have demonstrated that intranasal immunotherapy with allergens formulated in a nanoemulsion (NE) mucosal adjuvant suppresses Th2/IgE-mediated allergic responses and protects from allergen challenge in murine food allergy models. Protection conferred by this therapy is associated with strong suppr...

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Bibliographic Details
Main Authors: Mohammad Farazuddin, Jeffrey J. Landers, Katarzyna W. Janczak, Hayley K. Lindsey, Fred D. Finkelman, James R. Baker, Jessica J. O’Konek
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
adjuvant
alarmins
allergy treatment
food allergy
immunotherapy vaccines and mechanisms
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.599296/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.599296/full

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