Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts

Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts

Alpha-synuclein (αSyn) interferes with multiple steps of synaptic activity at pre-and post-synaptic terminals, however the mechanism/s by which αSyn alters neurotransmitter release and synaptic potentiation is unclear. By atomic force microscopy we show that human αSyn, when incubated with reconstit...

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Bibliographic Details
Main Authors: Marco Emanuele, Alessandro Esposito, Serena Camerini, Flavia Antonucci, Silvia Ferrara, Silvia Seghezza, Tiziano Catelani, Marco Crescenzi, Roberto Marotta, Claudio Canale, Michela Matteoli, Elisabetta Menna, Evelina Chieregatti
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:EBioMedicine
Subjects:
Alpha-synuclein
Lipid rafts
Post-synaptic density
Long term potentiation
Synaptic vesicles' mobilization
Casein kinase 2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416301256

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http://www.sciencedirect.com/science/article/pii/S2352396416301256

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