Mycobacterium tuberculosis-Specific T Cell Functional, Memory, and Activation Profiles in QuantiFERON-Reverters Are Consistent With Controlled Infection

Mycobacterium tuberculosis-Specific T Cell Functional, Memory, and Activation Profiles in QuantiFERON-Reverters Are Consistent With Controlled Infection

Reversion of immune sensitization tests for Mycobacterium tuberculosis (M.tb) infection, such as interferon-gamma release assays or tuberculin skin test, has been reported in multiple studies. We hypothesized that QuantiFERON-TB Gold (QFT) reversion is associated with a decline of M.tb-specific func...

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Bibliographic Details
Main Authors: Cheleka A. M. Mpande, Pia Steigler, Tessa Lloyd, Virginie Rozot, Boitumelo Mosito, Constance Schreuder, Timothy D. Reid, Nicole Bilek, Morten Ruhwald, Jason R. Andrews, Mark Hatherill, Francesca Little, Thomas J. Scriba, Elisa Nemes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
QuantiFERON reversion
memory T cell
donor unrestricted T cells
innate immune response
Mycobacterium tuberculosis infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.712480/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.712480/full

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