A sensitive, reproducible and objective immunofluorescence analysis method of dystrophin in individual fibers in samples from patients with duchenne muscular dystrophy.

A sensitive, reproducible and objective immunofluorescence analysis method of dystrophin in individual fibers in samples from patients with duchenne muscular dystrophy.

Duchenne muscular dystrophy (DMD) is characterized by the absence or reduced levels of dystrophin expression on the inner surface of the sarcolemmal membrane of muscle fibers. Clinical development of therapeutic approaches aiming to increase dystrophin levels requires sensitive and reproducible meas...

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Bibliographic Details
Main Authors: Chantal Beekman, Jessica A Sipkens, Janwillem Testerink, Stavros Giannakopoulos, Dyonne Kreuger, Judith C van Deutekom, Giles V Campion, Sjef J de Kimpe, Afrodite Lourbakos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0107494

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https://doi.org/10.1371/journal.pone.0107494

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