LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation

LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation

Abstract The innate immune system is critical for clearing infection, and is tightly regulated to avert excessive tissue damage. Nod1/2-Rip2 signaling, which is essential for initiating the innate immune response to bacterial infection and ER stress, is subject to many regulatory mechanisms. In this...

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Bibliographic Details
Main Authors: Ruiqing Yan, Zhihua Liu
Format: Article
Language:English
Published: SpringerOpen 2016-11-01
Series:Protein & Cell
Subjects:
LRRK2
Nod2
Rip2
NF-κB activation
Inflammation
Online Access:http://link.springer.com/article/10.1007/s13238-016-0326-x

Internet

http://link.springer.com/article/10.1007/s13238-016-0326-x

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