Outside-in induction of the IFITM3 trafficking system by infections, including SARS-CoV-2, in the pathobiology of Alzheimer’s disease

Outside-in induction of the IFITM3 trafficking system by infections, including SARS-CoV-2, in the pathobiology of Alzheimer’s disease

Background: IFITM3 is a viral restriction protein that enables sequestration of viral particles and subsequent trafficking to lysosomes. Recently, IFITM3 upregulation was found to induce gamma – secretase activity and the production of amyloid beta. The purpose of this study was to determine whether...

Full description

Bibliographic Details
Main Authors: George D. Vavougios, Christiane Nday, Sygliti-Henrietta Pelidou, Konstantinos I. Gourgoulianis, George Stamoulis, Triantafyllos Doskas, Sotirios G. Zarogiannis
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Alzheimer’s disease
IFITM3
Systems biology
Neuroimmunology
Epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354621000466

Internet

http://www.sciencedirect.com/science/article/pii/S2666354621000466

Similar Items