Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example

Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example

Idiosyncratic drug reactions (IDRs) are poorly understood, unpredictable, and not detected in preclinical studies. Although the cause of these reactions is likely multi-factorial, one hypothesis is that an underlying inflammatory state lowers the tolerance to a xenobiotic. Previously used in an infl...

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Bibliographic Details
Main Authors: Jeffrey F. Waring, Patricia E. Ganey, Robert A. Roth, Eric A. G. Blomme, David M. Nelson, Amy C. Ditewig, Jane F. Maddox, James P. Luyendyk, Lois D. Lehman-McKeeman, Vasanthi M. Bhaskaran, Michael J. Liguori
Format: Article
Language:English
Published: MDPI AG 2010-11-01
Series:International Journal of Molecular Sciences
Subjects:
idiosyncratic hepatotoxicity
liver
inflammation
rat
transcriptomics
Online Access:http://www.mdpi.com/1422-0067/11/11/4697/

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http://www.mdpi.com/1422-0067/11/11/4697/

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