Dickkopf1 Up-Regulation Induced by a High Concentration of Dexamethasone Promotes Rat Tendon Stem Cells to Differentiate Into Adipocytes

Dickkopf1 Up-Regulation Induced by a High Concentration of Dexamethasone Promotes Rat Tendon Stem Cells to Differentiate Into Adipocytes

Background/Aims: Dexamethasone (Dex)-induced spontaneous tendon rupture and decreased self-repair capability is very common in clinical practice. The metaplasia of adipose tissue in the ruptured tendon indicates that Dex may induce tendon stem cells (TSCs) to differentiate into adipocytes, but the m...

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Bibliographic Details
Main Authors: Wan Chen, Hong Tang, Xiangzhou Liu, Mei Zhou, Jiqiang Zhang, Kanglai Tang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Tendon stem cells
Adipocytes
Dickkopf1
GSK-3β
β-catenin
Dexamethasone
Online Access:http://www.karger.com/Article/FullText/438538

Internet

http://www.karger.com/Article/FullText/438538

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