Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions

Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions

CD8+ T cells are capable of recognizing mutation-derived neoantigens displayed by HLA class I molecules, thereby exhibiting the ability to distinguish between cancer and normal cells. However, accumulating evidence has shown that only a small fraction of nonsynonymous somatic mutations give rise to...

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Bibliographic Details
Main Authors: Tomoyo Shinkawa, Serina Tokita, Munehide Nakatsugawa, Yasuhiro Kikuchi, Takayuki Kanaseki, Toshihiko Torigoe
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
tumor antigen
neoantigen
cd8+ t cells
immunogenicity
hla ligandome
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1870062

Internet

http://dx.doi.org/10.1080/2162402X.2020.1870062

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