β-Ketophosphonates with Pentalenofuran Scaffolds Linked to the Ketone Group for the Synthesis of Prostaglandin Analogs

β-Ketophosphonates with Pentalenofuran Scaffolds Linked to the Ketone Group for the Synthesis of Prostaglandin Analogs

β-Ketophosphonates with pentalenofurane fragments linked to the keto group were synthesized. The bulky pentalenofurane skeleton is expected to introduce more hindrance in the prostaglandin analogues of type <b>III</b>, greater than that obtained with the bicyclo[3.3.0]oct(a)ene fragments...

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Bibliographic Details
Main Authors: Constantin I. Tănase, Constantin Drăghici, Miron Teodor Căproiu, Anamaria Hanganu, Gheorghe Borodi, Maria Maganu, Emese Gal, Lucia Pintilie
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
β-ketophosphonates
halogeno-pentalenofurane scafold
15-substituted prostaglandin analogs
dimethyl methanephosphonate
X-ray crystallography
15-bulky prostaglandin substituents
Online Access:https://www.mdpi.com/1422-0067/22/13/6787

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https://www.mdpi.com/1422-0067/22/13/6787

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