The Intrinsic Dynamics and Unfolding Process of an Antibody Fab Fragment Revealed by Elastic Network Model

The Intrinsic Dynamics and Unfolding Process of an Antibody Fab Fragment Revealed by Elastic Network Model

Antibodies have been increasingly used as pharmaceuticals in clinical treatment. Thermal stability and unfolding process are important properties that must be considered in antibody design. In this paper, the structure-encoded dynamical properties and the unfolding process of the Fab fragment of the...

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Bibliographic Details
Main Authors: Ji-Guo Su, Xiao Zhang, Xiao-Ming Han, Shu-Xin Zhao, Chun-Hua Li
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:International Journal of Molecular Sciences
Subjects:
fab fragment of antibody McPC603
intrinsic dynamics
unfolding process
Gaussian network model
native structural topology
Online Access:http://www.mdpi.com/1422-0067/16/12/26197

Internet

http://www.mdpi.com/1422-0067/16/12/26197

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