Folliculin haploinsufficiency causes cellular dysfunction of pleural mesothelial cells

Folliculin haploinsufficiency causes cellular dysfunction of pleural mesothelial cells

Abstract Birt–Hogg–Dubé syndrome (BHDS), an autosomal dominant inheritance disease caused by folliculin (FLCN) mutations, is associated with lung cysts and spontaneous pneumothorax. The possibility of FLCN haploinsufficiency in pleural mesothelial cells (PMCs) contributing to development of pneumoth...

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Bibliographic Details
Main Authors: Shouichi Okamoto, Hiroki Ebana, Masatoshi Kurihara, Keiko Mitani, Etsuko Kobayashi, Takuo Hayashi, Yasuhito Sekimoto, Koichi Nishino, Mizuto Otsuji, Toshio Kumasaka, Kazuhisa Takahashi, Kuniaki Seyama
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90184-9

Internet

https://doi.org/10.1038/s41598-021-90184-9

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