Functional cooperation between ASK1 and p21Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes

Functional cooperation between ASK1 and p21Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes

Abstract Both CDKN1A (p21 Waf1/Cip1) and Apoptosis signal-regulating kinase 1 (ASK1) play important roles in tumorigenesis. The role of p21 Waf1/Cip1 in attenuating ASK1-induced apoptosis by various stress conditions is well established. However, how ASK1 and p21 Waf1/Cip1 functionally interact duri...

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Bibliographic Details
Main Authors: Carlo De Blasio, Nagendra Verma, Marta Moretti, Samantha Cialfi, Azzurra Zonfrilli, Matteo Franchitto, Federica Truglio, Enrico De Smaele, Hidenori Ichijo, Isao Naguro, Isabella Screpanti, Claudio Talora
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00459-3

Internet

https://doi.org/10.1038/s41420-021-00459-3

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