Genotoxic effects of 1-nitropyrene in macrophages are mediated through a p53-dependent pathway involving cytochrome c release, caspase activation, and PARP-1 cleavage

Genotoxic effects of 1-nitropyrene in macrophages are mediated through a p53-dependent pathway involving cytochrome c release, caspase activation, and PARP-1 cleavage

Genotoxic stress from environmental pollutants plays a critical role in cytotoxicity. The most abundant nitro-polycyclic aromatic hydrocarbon in environmental pollutants, 1-nitropyrene (1-NP), is generated during fossil fuel, diesel, and biomass combustion under sunlight. Macrophages, the key regula...

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Bibliographic Details
Main Authors: Sheng-Wen Wu, Chun-Hung Su, Yung-Chuan Ho, Rosa Huang-Liu, Ching-Chi Tseng, Yun-Wei Chiang, Kun-Lin Yeh, Shiuan-Shinn Lee, Wen-Ying Chen, Chun-Jung Chen, Yi-Ching Li, Chien-Ying Lee, Yu-Hsiang Kuan
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
1-Nitropyrene
Genotoxicity
p53-dependent pathway
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321001731

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http://www.sciencedirect.com/science/article/pii/S0147651321001731

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