The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.

The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.

Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2). We determined whether TNNT2 mutations cause cardiomyopathies by altering cTnT function or quantity; whether the severity of DCM is related to the ratio of mutan...

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Bibliographic Details
Main Authors: Ferhaan Ahmad, Sanjay K Banerjee, Michele L Lage, Xueyin N Huang, Stephen H Smith, Samir Saba, Jennifer Rager, David A Conner, Andrzej M Janczewski, Kimimasa Tobita, Joseph P Tinney, Ivan P Moskowitz, Antonio R Perez-Atayde, Bradley B Keller, Michael A Mathier, Sanjeev G Shroff, Christine E Seidman, J G Seidman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2441440?pdf=render

Internet

http://europepmc.org/articles/PMC2441440?pdf=render

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