IRF-8 Controls Melanoma Progression by Regulating the Cross Talk between Cancer and Immune Cells within the Tumor Microenvironment

IRF-8 Controls Melanoma Progression by Regulating the Cross Talk between Cancer and Immune Cells within the Tumor Microenvironment

The transcription factor interferon regulatory factor-8 (IRF-8) is crucial for myeloid cell development and immune response and also acts as a tumor suppressor gene. Here, we analyzed the role of IRF-8 in the cross talk between melanoma cells and tumor-infiltrating leukocytes. B16-F10 melanoma cell...

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Bibliographic Details
Main Authors: Fabrizio Mattei, Giovanna Schiavoni, Paola Sestili, Francesca Spadaro, Alessandra Fragale, Antonella Sistigu, Valeria Lucarini, Massimo Spada, Massimo Sanchez, Stefania Scala, Angela Battistini, Filippo Belardelli, Lucia Gabriele
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612800583

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http://www.sciencedirect.com/science/article/pii/S1476558612800583

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