Improved chemotherapy modeling with RAG-based immune deficient mice.

Improved chemotherapy modeling with RAG-based immune deficient mice.

We have previously characterized an acute myeloid leukemia (AML) chemotherapy model for SCID-based immune deficient mice (NSG and NSGS), consisting of 5 days of cytarabine (AraC) and 3 days of anthracycline (doxorubicin), to simulate the standard 7+3 chemotherapy regimen many AML patients receive. W...

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Bibliographic Details
Main Authors: Mark Wunderlich, Nicole Manning, Christina Sexton, Anthony Sabulski, Luke Byerly, Eric O'Brien, John P Perentesis, Benjamin Mizukawa, James C Mulloy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0225532

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https://doi.org/10.1371/journal.pone.0225532

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