Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

SUMMARY Back pain related to intervertebral disc degeneration is the most common musculoskeletal problem, with a lifetime prevalence of 82%. The lack of effective treatment for this widespread problem is directly related to our limited understanding of disc development, maintenance and degeneration....

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Bibliographic Details
Main Authors: Matthew R. McCann, Owen J. Tamplin, Janet Rossant, Cheryle A. Séguin
Format: Article
Language:English
Published: The Company of Biologists 2012-01-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/5/1/73