DPD status and fluoropyrimidines-based treatment: high activity matters too

DPD status and fluoropyrimidines-based treatment: high activity matters too

Abstract Background Dihydropyrimidine dehydrogenase (DPD) status is an indicator of a marked risk for toxicity following fluoropyrimidine (FP)-based chemotherapy. This notion is well-established for low DPD status but little is known about the clinical impact of high DPD activity. This study examine...

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Bibliographic Details
Main Authors: Emmanuel Chamorey, Eric Francois, Marie-Christine Etienne, Jean-Marc Ferrero, Frederic Peyrade, Emmanuel Barranger, Alexandre Bozec, Rémy Largillier, Ophelie Cassuto, Julien Viotti, Renaud Schiappa, Gérard Milano
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Cancer
Subjects:
Dihydropyrimidine dehydrogenase
Capecitabine
5-fluorouracil
Digestive neoplasms
Breast neoplasms
Head and neck neoplasms
Online Access:http://link.springer.com/article/10.1186/s12885-020-06907-0

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http://link.springer.com/article/10.1186/s12885-020-06907-0

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