Desensitized D2 autoreceptors are resistant to trafficking

Abstract Dendritic release of dopamine activates dopamine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the excitability of dopamine neurons. This study used tagged D2 receptors to identify the localization and distribution of these receptors in living midbr...

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Bibliographic Details
Main Authors: Brooks G. Robinson, James R. Bunzow, Jonathan B. Grimm, Luke D. Lavis, Joshua T. Dudman, Jennifer Brown, Kim A. Neve, John T. Williams
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04728-z