Autocrine Growth Hormone (GH)-Mediated Triptolide Resistance Overcame by Metformin Co-Treatment in MDA-MB231 Breast Cancer Cells Through ER Stress Pathway

Autocrine Growth Hormone (GH)-Mediated Triptolide Resistance Overcame by Metformin Co-Treatment in MDA-MB231 Breast Cancer Cells Through ER Stress Pathway

Breast cancer is the most common cancer in women worldwide and the second most common cancer overall. Autocrine growth hormone (GH) expression induced cell proliferation, growth, invasion-metastasis in vitro and in vivo breast cancer models. Moreover, forced GH signaling acts as a drug resistance pr...

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Bibliographic Details
Main Authors: Amani Abdulmunem, Pınar Obakan-Yerlikaya, Elif-Damla Arisan, Ajda Coker-Gurkan
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Proceedings
Subjects:
breast cancer
autocrine growth hormone
triptolide
metformin
Online Access:https://www.mdpi.com/2504-3900/40/1/9

Internet

https://www.mdpi.com/2504-3900/40/1/9

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