Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3×Tg-AD mice.

Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3×Tg-AD mice.

Spectrins line the intracellular surface of plasmalemma and play a critical role in supporting cytoskeletal stability and flexibility. Spectrins can be proteolytically degraded by calpains and caspases, yielding breakdown products (SBDPs) of various molecular sizes, with SBDP120 being largely derive...

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Bibliographic Details
Main Authors: Yan Cai, Hai-Xia Zhu, Jian-Ming Li, Xue-Gang Luo, Peter R Patrylo, Gregory M Rose, Jackson Streeter, Ron Hayes, Kevin K W Wang, Xiao-Xin Yan, Andreas Jeromin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3377681?pdf=render

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http://europepmc.org/articles/PMC3377681?pdf=render

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