Hit hard and early: analysing the effects of high-dose methylprednisolone on nailfold capillary changes and biomarkers in very early systemic sclerosis: study protocol for a 12-week randomised controlled trial

Hit hard and early: analysing the effects of high-dose methylprednisolone on nailfold capillary changes and biomarkers in very early systemic sclerosis: study protocol for a 12-week randomised controlled trial

Abstract Background Mounting evidence indicates that inflammatory mechanisms drive systemic sclerosis (SSc) vasculopathy and fibrosis, especially early in the disease. Therefore, patients with very early SSc could benefit from early treatments targeting inflammation. Glucocorticoids are among the mo...

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Bibliographic Details
Main Authors: Wieneke M. T. van den Hombergh, Brigit E. Kersten, Hanneke K. A. Knaapen-Hans, Rogier M. Thurlings, Peter M. van der Kraan, Frank H. J. van den Hoogen, Jaap Fransen, Madelon C. Vonk
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Trials
Subjects:
Systemic sclerosis
Methylprednisolone
Randomised controlled trial
Very early diagnosis of systemic sclerosis
Nailfold capillaroscopy
Online Access:http://link.springer.com/article/10.1186/s13063-018-2798-x

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http://link.springer.com/article/10.1186/s13063-018-2798-x

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